Interleukin-1 alpha

IL1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ILA, 2KKI, 2L5X
Identifiers
Aliases	IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha
External IDs	OMIM: 147760 MGI: 96542 HomoloGene: 480 GeneCards: IL1A
Gene location (Human) Chr. Chromosome 2 (human) Band 2q14.1 Start 112,773,915 bp End 112,784,590 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 F1|2 62.9 cM Start 129,299,610 bp End 129,309,972 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine activity • protein binding • copper ion binding • interleukin-1 receptor binding Cellular component • cytosol • extracellular region • cytoplasm • extracellular space Biological process • cellular response to heat • response to copper ion • cytokine-mediated signaling pathway • positive regulation of cytokine secretion • positive regulation of angiogenesis • positive regulation of gene expression • immune response • connective tissue replacement involved in inflammatory response wound healing • positive regulation of protein secretion • extrinsic apoptotic signaling pathway in absence of ligand • ectopic germ cell programmed cell death • positive regulation of vascular endothelial growth factor production • cell proliferation • inflammatory response • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of mitotic nuclear division • positive regulation of cell division • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • apoptotic process • positive regulation of interleukin-2 biosynthetic process • positive regulation of interleukin-6 production • interleukin-1-mediated signaling pathway • positive regulation of neutrophil extravasation • fever generation • positive regulation of monocyte chemotactic protein-1 production • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3552	16175
Ensembl	ENSG00000115008	ENSMUSG00000027399
UniProt	P01583	P01582
RefSeq (mRNA)	NM_000575	NM_010554
RefSeq (protein)	NP_000566	NP_034684
Location (UCSC)	Chr 2: 112.77 – 112.78 Mb	Chr 2: 129.3 – 129.31 Mb
PubMed search

2ILA, 2KKI, 2L5X

3552

16175

ENSG00000115008

ENSMUSG00000027399

P01583

P01582

NM_000575

NM_010554

NP_000566

NP_034684

Interleukin 1 alpha (IL-1α) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. IL-1α inhibitors are being developed to interrupt those processes and treat diseases.

IL-1α is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. It is on the pathway that activates tumor necrosis factor-alpha.

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Wikipedia