Interleukin-15

IL15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XQB, 2Z3Q, 2Z3R, 4GS7
Identifiers
Aliases	IL15, IL-15, interleukin 15
External IDs	OMIM: 600554 MGI: 103014 HomoloGene: 487 GeneCards: IL15
Gene location (Human) Chr. Chromosome 4 (human) Band No data available Start 141,636,599 bp End 141,733,987 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band No data available Start 82,331,632 bp End 82,403,222 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding • cytokine receptor binding • cytokine activity Cellular component • nucleus • integral component of plasma membrane • Golgi apparatus • endosome • nucleoplasm • membrane • cell surface • extracellular region • extracellular space • cytoplasm • cytosol • nuclear speck Biological process • negative regulation of smooth muscle cell proliferation • cell maturation • extrathymic T cell selection • positive regulation of T cell proliferation • regulation of defense response to virus by host • positive regulation of inflammatory response • response to nutrient levels • positive regulation of protein O-linked glycosylation • positive regulation of interleukin-17 production • hyaluronan metabolic process • positive regulation of natural killer cell differentiation • regulation of T cell differentiation • positive regulation of tissue remodeling • cellular response to vitamin D • lymph node development • natural killer cell differentiation • positive regulation of natural killer cell proliferation • cell-cell signaling • skeletal muscle atrophy • signal transduction • aging • NK T cell proliferation • positive regulation of immune response • inflammatory response • immune response • positive regulation of cell proliferation • tyrosine phosphorylation of STAT protein • interleukin-15-mediated signaling pathway • positive regulation of tyrosine phosphorylation of STAT protein Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3600	16168
Ensembl	ENSG00000164136	ENSMUSG00000031712
UniProt	P40933	P48346
RefSeq (mRNA)	NM_000585 NM_172174 NM_172175	NM_001254747 NM_008357
RefSeq (protein)	NP_000576 NP_751915	NP_001241676 NP_032383
Location (UCSC)	Chr 4: 141.64 – 141.73 Mb	Chr 4: 82.33 – 82.4 Mb
PubMed search

2XQB, 2Z3Q, 2Z3R, 4GS7

3600

16168

ENSG00000164136

ENSMUSG00000031712

P40933

P48346

NM_000585
NM_172174
NM_172175

NM_001254747
NM_008357

NP_000576
NP_751915

NP_001241676
NP_032383

Interleukin-15 (IL-15) is a cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells.

...
Wikipedia