Inositol monophosphatase 3

IMPAD1
Identifiers
Aliases	IMPAD1, GPAPP, IMP 3, IMP-3, IMPA3, inositol monophosphatase domain containing 1
External IDs	MGI: 1915720 HomoloGene: 9852 GeneCards: IMPAD1
Gene location (Human) Chr. Chromosome 8 (human) Band 8q12.1 Start 56,957,933 bp End 56,993,844 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A1 Start 4,762,484 bp End 4,793,355 bp
Gene ontology Molecular function • inositol monophosphate 1-phosphatase activity • inositol monophosphate 4-phosphatase activity • hydrolase activity • inositol monophosphate phosphatase activity • metal ion binding • inositol monophosphate 3-phosphatase activity • 3'-nucleotidase activity • 3'(2'),5'-bisphosphate nucleotidase activity Cellular component • integral component of membrane • membrane • Golgi apparatus • nucleus • cytosol • nuclear body • Golgi lumen Biological process • skeletal system development • chondrocyte development • embryonic digit morphogenesis • phosphatidylinositol phosphorylation • chondroitin sulfate metabolic process • endochondral ossification • post-embryonic development • inositol biosynthetic process • dephosphorylation • 3'-phosphoadenosine 5'-phosphosulfate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54928	242291
Ensembl	ENSG00000104331	ENSMUSG00000066324
UniProt	Q9NX62	Q80V26
RefSeq (mRNA)	NM_017813	NM_177730
RefSeq (protein)	NP_060283	NP_808398
Location (UCSC)	Chr 8: 56.96 – 56.99 Mb	Chr 8: 4.76 – 4.79 Mb
PubMed search

54928

242291

ENSG00000104331

ENSMUSG00000066324

Q9NX62

Q80V26

NM_017813

NM_177730

NP_060283

NP_808398

Inositol monophosphatase 3 also known as inositol monophosphatase domain-containing protein 1 (IMPAD1) is an enzyme that in humans is encoded by the IMPAD1 gene.

This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP).

Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1.

...
Wikipedia