Indigenous peoples in Venezuela, or Native Venezuelans, form about 2% of the total population of Venezuela, although many Venezuelans share some indigenous ancestry. Indigenous peoples are concentrated in the southern Amazon rainforest state of Amazonas, where they make up nearly 50% of the population, and in the Andes of the western state of Zulia. The most numerous indigenous people, at about 200,000, is the Venezuelan part of the Wayuu (or Guajiro) people who primarily live in Zulia between Lake Maracaibo and the Colombian border. Another 100,000 or so indigenous people live in the sparsely populated southeastern states of Amazonas, Bolívar, and Delta Amacuro. There are at least 26 indigenous groups in Venezuela, including the Ya̧nomamö, Pemon, Warao people, Baniwa people, Kali'na people, Motilone Barí, Ye'kuana, and Yaruro.
It is not known how many people lived in Venezuela before the Spanish Conquest; it may have been around a million people and in addition to today's peoples included groups such as the Auaké, Caquetio, Mariche, Pemon, Piaroa and Timoto-cuicas. The number was much reduced after the Conquest, mainly through the spread of new diseases from Europe. There were two main north-south axes of pre-Columbian population, producing maize in the west and manioc in the east. Large parts of the llanos plains were cultivated through a combination of slash and burn and permanent settled agriculture. The indigenous peoples of Venezuela had already encountered crude oils and asphalts that seeped up through the ground to the surface. Known to the locals as mene, the thick, black liquid was primarily used for medicinal purposes, as an illumination source, and for the caulking of canoes.