Immunostimulant

Immunostimulants, also known as immunostimulators, are substances (drugs and nutrients) that stimulate the immune system by inducing activation or increasing activity of any of its components. One notable example is the granulocyte macrophage colony-stimulating factor.

There are two main categories of immunostimulants:

Many endogenous substances are non-specific immunostimulators. For example, female sex hormones are known to stimulate both adaptive and innate immune responses. Some autoimmune diseases such as lupus erythematosus strike women preferentially, and their onset often coincides with puberty. Other hormones appear to regulate the immune system as well, most notably prolactin, growth hormone and vitamin D.

Some publications point towards the effect of deoxycholic acid (DCA) as an immunostimulant of the non-specific immune system, activating its main actors, the macrophages. According to these publications, a sufficient amount of DCA in the human body corresponds to a good immune reaction of the non-specific immune system.

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