Ibutamoren

Ibutamoren
Clinical data

ATC code	None
Legal status
Legal status	US: Unscheduled
Pharmacokinetic data
Biological half-life	4–6 hours (in beagles);IGF-1 levels remain elevated in humans with a single oral dose for up to 24 hours
Identifiers
IUPAC name (R)-1'-(2-methylalanyl-O-benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4'-piperidine]
Synonyms	2-Amino-2-methyl-N-[1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-(phenylmethoxy)propan-2-yl]propanamide
CAS Number	159634-47-6^Y
PubChem CID	9939050
ChemSpider	154975
UNII	GJ0EGN38UL
ECHA InfoCard	100.236.734
Chemical and physical data
Formula	C₂₇H₃₆N₄O₅S
Molar mass	528.662 g/mol
3D model (Jmol)	Interactive image
SMILES O=S(C)(=O)N(C2)c1ccccc1C23CCN(CC3)C(=O)C(NC(=O)C(N)(C)C)COCc4ccccc4
InChI InChI=1S/C27H36N4O5S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27/h4-12,22H,13-19,28H2,1-3H3,(H,29,33)/t22-/m1/s1 Key:UMUPQWIGCOZEOY-JOCHJYFZSA-N

Ibutamoren (INN) (developmental code names MK-677, MK-0677, L-163,191) is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including GH and insulin-like growth factor 1 (IGF-1), but without affecting cortisol levels. MK677 has shown to sustain activation of GH-IGF-1 Axis and increase in lean body mass but no change in total fat mass or visceral fat. It is currently under development as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly.

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Wikipedia