Growth hormone secretagogue receptor

GHSR
Identifiers
Aliases	GHSR, GHDP, growth hormone secretagogue receptor
External IDs	OMIM: 601898 MGI: 2441906 HomoloGene: 57161 GeneCards: GHSR
Targeted by Drug
examorelin
Gene ontology Molecular function • hormone binding • signal transducer activity • peptide hormone binding • growth hormone-releasing hormone receptor activity • growth hormone secretagogue receptor activity • G-protein coupled receptor activity Cellular component • integral component of membrane • membrane • cell surface • neuron projection • membrane raft • plasma membrane Biological process • negative regulation of interleukin-6 biosynthetic process • negative regulation of interleukin-1 beta production • negative regulation of insulin secretion • regulation of synapse assembly • negative regulation of tumor necrosis factor biosynthetic process • regulation of hindgut contraction • decidualization • positive regulation of insulin-like growth factor receptor signaling pathway • positive regulation of fatty acid metabolic process • hormone-mediated signaling pathway • positive regulation of multicellular organism growth • cellular response to insulin stimulus • response to food • response to hormone • actin polymerization or depolymerization • negative regulation of inflammatory response • signal transduction • positive regulation of appetite • growth hormone secretion • G-protein coupled receptor signaling pathway • adult feeding behavior Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2693	208188
Ensembl	ENSG00000121853	ENSMUSG00000051136
UniProt	Q92847	Q99P50
RefSeq (mRNA)	NM_198407 NM_004122	NM_177330
RefSeq (protein)	NP_004113 NP_940799	NP_796304.1 NP_796304
Location (UCSC)	Chr 3: 172.45 – 172.45 Mb	Chr 3: 27.37 – 27.38 Mb
PubMed search

2693

208188

ENSG00000121853

ENSMUSG00000051136

Q92847

Q99P50

NM_198407
NM_004122

NM_177330

NP_004113
NP_940799

NP_796304.1
NP_796304

Growth hormone secretagogue receptor (GHSR), or ghrelin receptor, is a G protein-coupled receptor that binds ghrelin and plays a role in energy homeostasis and regulation of body weight. In the brain, they are located in the hypothalamic ventromedial nucleus and arcuate nucleus, as well as in ventral tegmental area dopamine neurons projecting to the nucleus accumbens.

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