IRF6

IRF6
Identifiers
Aliases	IRF6, LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1, interferon regulatory factor 6
External IDs	OMIM: 607199 MGI: 1859211 HomoloGene: 4479 GeneCards: IRF6
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • regulatory region DNA binding • protein binding Cellular component • cytoplasm • extracellular exosome • nucleus • cytosol Biological process • cell differentiation • regulation of transcription, DNA-templated • cell development • interferon-gamma-mediated signaling pathway • transcription, DNA-templated • mammary gland epithelial cell differentiation • keratinocyte differentiation • positive regulation of transcription, DNA-templated • keratinocyte proliferation • type I interferon signaling pathway • cell cycle arrest • skin development • negative regulation of cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3664	54139
Ensembl	ENSG00000117595	ENSMUSG00000026638
UniProt	O14896	P97431
RefSeq (mRNA)	NM_006147 NM_001206696	NM_016851 NM_178083
RefSeq (protein)	NP_001193625 NP_006138	NP_058547.2 NP_058547
Location (UCSC)	Chr 1: 209.79 – 209.81 Mb	Chr 1: 193.15 – 193.17 Mb
PubMed search

3664

54139

ENSG00000117595

ENSMUSG00000026638

O14896

P97431

NM_006147
NM_001206696

NM_016851
NM_178083

NP_001193625
NP_006138

NP_058547.2
NP_058547

Interferon regulatory factor 6 also known as IRF6 is a protein that in humans is encoded by the IRF6 gene.

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain.

The function of IRF6 is related to the formation of connective tissue, for example that of the palate. This gene encodes a member of the interferon regulatory transcription factor (IRF) family.

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Wikipedia