IPF1

PDX1
Identifiers
Aliases	PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1, pancreatic and duodenal homeobox 1
External IDs	MGI: 102851 HomoloGene: 175 GeneCards: PDX1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • protein complex binding • transcription factor binding • chromatin binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • core promoter sequence-specific DNA binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component • cytoplasm • cytosol • nuclear speck • intracellular • nucleus • nucleoplasm Biological process • exocrine pancreas development • positive regulation of insulin secretion • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • response to cytokine • cell differentiation • positive regulation of cell death • response to fatty acid • regulation of transcription, DNA-templated • response to iron(II) ion • response to vitamin • response to organic cyclic compound • glucose homeostasis • regulation of transcription from RNA polymerase II promoter • response to nicotine • response to leucine • response to glucocorticoid • insulin secretion • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • response to glucose • generation of precursor metabolites and energy • stem cell differentiation • transcription, DNA-templated • multicellular organism development • positive regulation of transcription, DNA-templated • response to lipid • central nervous system development • response to alkaloid • response to nutrient levels • regulation of cell proliferation • response to wounding • animal organ regeneration • positive regulation of cell proliferation • nitric oxide mediated signal transduction • glucose metabolic process • animal organ morphogenesis • detection of glucose • regulation of gene expression • response to chlorate • pancreas development • liver development • smoothened signaling pathway • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of DNA binding • morphogenesis of embryonic epithelium • digestive tract development • negative regulation of transcription, DNA-templated • negative regulation of type B pancreatic cell apoptotic process • type B pancreatic cell differentiation • response to drug • negative regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • transdifferentiation • animal organ senescence • endocrine pancreas development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3651	18609
Ensembl	ENSG00000139515	ENSMUSG00000029644
UniProt	P52945	P52946
RefSeq (mRNA)	NM_000209	NM_008814
RefSeq (protein)	NP_000200	NP_032840.1 NP_032840
Location (UCSC)	Chr 13: 27.92 – 27.93 Mb	Chr 5: 147.27 – 147.28 Mb
PubMed search

3651

18609

ENSG00000139515

ENSMUSG00000029644

P52945

P52946

NM_000209

NM_008814

NP_000200

NP_032840.1
NP_032840

PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. In humans this protein is encoded by the PDX1 gene, which was formerly known as IPF1.

In pancreatic development, Pdx1 is expressed by a population of cells in the posterior foregut region of the definitive endoderm, and Pdx1⁺epithelial cells give rise to the developing pancreatic buds, and eventually, the whole of the pancreas—its exocrine, endocrine, and ductal cell populations. Pancreatic Pdx1⁺ cells first arise at mouse embryonic day 8.5-9.0 (E8.5-9.0), and Pdx1 expression continues until E12.0-E12.5, after which Pdx1 expression decreases and the pancreas is formed—other transcription factors are expressed, controlling the fates of the cells of the newly formed pancreas. Homozygous Pdx1 knockout mice form pancreatic buds but fail to develop a pancreas, and transgenic mice in which tetracycline application results in death of Pdx1⁺ cells are almost completely apancreatic if doxycycline (tetracycline derivative) is administered throughout the pregnancy of these transgenic mice, illustrating the necessity of Pdx1⁺ cells in pancreatic development.

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