IMPDH2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1B3O, 1NF7, 1NFB

Identifiers

Aliases

IMPDH2, IMPD2, IMPDH-II, IMP (inosine 5'-monophosphate) dehydrogenase 2, inosine monophosphate dehydrogenase 2

External IDs

MGI: 109367 HomoloGene: 48919 GeneCards: IMPDH2

Targeted by Drug

, mycophenolic acid, ribavirin, thioguanine anhydrous

Gene ontology
Molecular function	• DNA binding • metal ion binding • catalytic activity • protein binding • RNA binding • oxidoreductase activity • nucleotide binding • IMP dehydrogenase activity
Cellular component	• cytoplasm • membrane • peroxisomal membrane • extracellular exosome • nucleus • extracellular region • cytosol • secretory granule lumen • ficolin-1-rich granule lumen
Biological process	• cellular response to interleukin-4 • purine nucleotide biosynthetic process • retina development in camera-type eye • purine ribonucleoside monophosphate biosynthetic process • lymphocyte proliferation • GMP biosynthetic process • protein homotetramerization • oxidation-reduction process • GTP biosynthetic process • neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3615


23918

Ensembl


ENSG00000178035


ENSMUSG00000062867

UniProt


P12268


P24547

RefSeq (mRNA)


NM_000884


NM_011830

RefSeq (protein)


NP_000875


NP_035960.2 NP_035960

Location (UCSC)

Chr 3: 49.02 – 49.03 Mb

Chr 9: 108.56 – 108.57 Mb

PubMed search

1B3O, 1NF7, 1NFB

NP_035960.2
NP_035960

Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene.

IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. IMPDH2 catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate.

...
Wikipedia