IMPDH1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1JCN

Identifiers

Aliases

IMPDH1, IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608, IMP (inosine 5'-monophosphate) dehydrogenase 1, inosine monophosphate dehydrogenase 1

External IDs

MGI: 96567 HomoloGene: 68096 GeneCards: IMPDH1

Targeted by Drug

, mycophenolic acid, ribavirin, thioguanine anhydrous

Gene ontology
Molecular function	• metal ion binding • catalytic activity • RNA binding • nucleic acid binding • oxidoreductase activity • DNA binding • IMP dehydrogenase activity
Cellular component	• cytoplasm • nucleus • extracellular region • cytosol • secretory granule lumen • azurophil granule lumen • ficolin-1-rich granule lumen
Biological process	• purine nucleotide biosynthetic process • purine ribonucleoside monophosphate biosynthetic process • lymphocyte proliferation • GMP biosynthetic process • oxidation-reduction process • GTP biosynthetic process • neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3614


23917

Ensembl


ENSG00000106348


ENSMUSG00000003500

UniProt


P20839


P50096

RefSeq (mRNA)

NM_000883 NM_001102605 NM_001142573 NM_001142574 NM_001142575
NM_001142576 NM_001304521 NM_183243


NM_011829 NM_001302933 NM_001302934

RefSeq (protein)

NP_000874 NP_001096075 NP_001136045 NP_001136046 NP_001136047
NP_001136048 NP_001291450 NP_899066

NP_001289862.1 NP_001289863.1 NP_035959.2 NP_001289862 NP_001289863
NP_035959

Location (UCSC)

Chr 7: 128.39 – 128.41 Mb

Chr 6: 29.2 – 29.22 Mb

PubMed search

NM_001142576
NM_001304521
NM_183243

NM_011829
NM_001302933
NM_001302934

NP_001136048
NP_001291450
NP_899066

NP_035959

Inosine-5'-monophosphate dehydrogenase 1, also known as IMP dehydrogenase 1, is an enzyme that in humans is encoded by the IMPDH1 gene.

IMP dehydrogenase 1 acts as a homotetramer to regulate cell growth. IMPDH1 is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides.

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