IL3RA

IL3RA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JZJ
Identifiers
Aliases	IL3RA, CD123, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, interleukin 3 receptor subunit alpha
External IDs	MGI: 96553 HomoloGene: 48088 GeneCards: IL3RA
Gene ontology Molecular function • cytokine receptor activity • interleukin-3 receptor activity • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity Cellular component • integral component of membrane • plasma membrane • membrane • intracellular Biological process • MAPK cascade • cytokine-mediated signaling pathway • positive regulation of GTPase activity • cellular response to interleukin-3 • peptidyl-tyrosine phosphorylation • interleukin-3-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3563	16188
Ensembl	ENSG00000185291	ENSMUSG00000068758
UniProt	P26951	P26952
RefSeq (mRNA)	NM_001267713 NM_002183	NM_008369
RefSeq (protein)	NP_001254642 NP_002174	NP_032395
Location (UCSC)	Chr X: 1.34 – 1.38 Mb	Chr 14: 14.35 – 14.36 Mb
PubMed search

4JZJ

3563

16188

ENSG00000185291

ENSMUSG00000068758

P26951

P26952

NM_001267713
NM_002183

NM_008369

NP_001254642
NP_002174

NP_032395

Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene.

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.

IL3RA has been shown to interact with Interleukin 3.

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Wikipedia