IL17A

IL17A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VXS, 4HR9, 4HSA, 4QHU, 5HHV, 5HHX
Identifiers
Aliases	IL17A, CTLA8, IL-17, IL-17A, IL17, CTLA-8, interleukin 17A
External IDs	MGI: 107364 HomoloGene: 1651 GeneCards: IL17A
Gene ontology Molecular function • cytokine activity • protein binding Cellular component • external side of plasma membrane • extracellular region • extracellular space Biological process • positive regulation of cytokine production involved in inflammatory response • positive regulation of interleukin-6 secretion • cell-cell signaling • positive regulation of osteoclast differentiation • cell death • defense response to fungus • cellular response to interleukin-1 • immune response • fibroblast activation • positive regulation of interleukin-23 production • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • inflammatory response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3605	16171
Ensembl	ENSG00000112115	ENSMUSG00000025929
UniProt	Q16552	Q62386
RefSeq (mRNA)	NM_002190	NM_010552
RefSeq (protein)	NP_002181	NP_034682.1 NP_034682
Location (UCSC)	Chr 6: 52.19 – 52.19 Mb	Chr 1: 20.73 – 20.73 Mb
PubMed search

2VXS, 4HR9, 4HSA, 4QHU, 5HHV, 5HHX

3605

16171

ENSG00000112115

ENSMUSG00000025929

Q16552

Q62386

NM_002190

NM_010552

NP_002181

NP_034682.1
NP_034682

Interleukin-17A is a protein that in humans is encoded by the IL17A gene.

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).

...
Wikipedia