IDH2

IDH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JA8
Identifiers
Aliases	IDH2, D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH, isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
External IDs	MGI: 96414 HomoloGene: 37590 GeneCards: IDH2
Gene ontology Molecular function • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor • oxidoreductase activity • isocitrate dehydrogenase activity • NAD binding • magnesium ion binding • metal ion binding • isocitrate dehydrogenase (NADP+) activity Cellular component • mitochondrial inner membrane • cytosol • mitochondrial matrix • peroxisome • extracellular exosome • mitochondrion Biological process • oxidation-reduction process • 2-oxoglutarate metabolic process • glyoxylate cycle • carbohydrate metabolic process • isocitrate metabolic process • tricarboxylic acid cycle • NADP biosynthetic process • negative regulation of glial cell proliferation • negative regulation of glial cell migration • negative regulation of matrix metallopeptidase secretion • mitochondrion organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3418	269951
Ensembl	ENSG00000182054	ENSMUSG00000030541
UniProt	P48735	P54071
RefSeq (mRNA)	NM_002168 NM_001289910 NM_001290114	NM_173011
RefSeq (protein)	NP_001276839 NP_001277043 NP_002159	NP_766599.2 NP_766599
Location (UCSC)	Chr 15: 90.08 – 90.1 Mb	Chr 7: 80.09 – 80.12 Mb
PubMed search

4JA8

3418

269951

ENSG00000182054

ENSMUSG00000030541

P48735

P54071

NM_002168
NM_001289910
NM_001290114

NM_173011

NP_001276839
NP_001277043
NP_002159

NP_766599.2
NP_766599

Isocitrate dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene.

Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the , and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by the IDH2 gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Somatic mosaic mutations of this gene have also been found associated to Ollier disease and Maffucci syndrome.

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Wikipedia