ICI-85966

ICI-85966

Identifiers
IUPAC name [4-[(E)-4-[4-[Bis(2-chloroethyl)carbamoyloxy]phenyl]hex-3-en-3-yl]phenyl] N,N-bis(2-chloroethyl)carbamate
Synonyms	Stilbostat
CAS Number	15470-58-3
PubChem CID	3037081
ChemSpider	2300916
Chemical and physical data
Formula	C28H34Cl4N2O4
Molar mass	604.39256 g/mol
3D model (JSmol)	Interactive image
SMILES CC/C(=C(/CC)\C1=CC=C(C=C1)OC(=O)N(CCCl)CCCl)/C2=CC=C(C=C2)OC(=O)N(CCCl)CCCl
InChI InChI=1S/C28H34Cl4N2O4/c1-3-25(21-5-9-23(10-6-21)37-27(35)33(17-13-29)18-14-30)26(4-2)22-7-11-24(12-8-22)38-28(36)34(19-15-31)20-16-32/h5-12H,3-4,13-20H2,1-2H3/b26-25+ Key:BOIZOYRDXIYMCY-OCEACIFDSA-N

ICI-85966 (former tentative brand name Stilbostat), also known as diethylstilbestrol (DES) bis(di(2-chloroethyl)carbamate), is a synthetic, nonsteroidal estrogen and alkylating antineoplastic agent of the stilbestrol group and a cytostatic nitrogen mustard ester of diethylstilbestrol (DES) that was developed for the treatment of breast cancer and prostate cancer but was never marketed. (possibly due to the toxcitity of DES) It was found to markedly improve the clinical state in approximately 65% of women treated with it for advanced breast cancer in a clinical study.