Honjō Domain (本荘藩 Honjō-han?) was a feudal domain in Edo period Japan, located in Dewa Province (modern-day Akita Prefecture), Japan. It was centered on Honjō Castle in what is now the city of Yurihonjō, Akita.
Much of Dewa Province was controlled by the powerful Mogami clan during the Sengoku period. The Mogami established a subsidiary holding centered on Honjō Castle in the center of the Yuri region of central Dewa Province in 1610. However, the Mogami were dispossessed by the Tokugawa shogunate in 1622, with the majority of their holdings going to the Satake clan, who were transferred from Hitachi Province to the much smaller holding of Kubota Domain.
Rokugō Masanori, a relatively minor samurai from Senboku Country in Dewa Province served Toyotomi Hideyoshi at the Battle of Odawara in 1590 and was confirmed in his ancestral holdings of 4,500 koku in Dewa Province. He sided with Tokugawa Ieyasu at the Battle of Sekigahara against his nominal overlords, the Onodera clan, and was promoted to the status of a 10,000 koku daimyo, based at Hitachi-Fuchū Domain, with his holdings scattered between Dewa and Hitachi Provinces. When the Mogami clan was dispossessed, the Tokugawa shogunate transferred him in 1623 from Hitachi to the newly created Honjō Domain, and increased his revenues to 20,000 koku, which were all consolidated in the form of 103 villages in Yuki County where his descendants ruled for 11 generations to the Meiji restoration.