Following the Venezuelan War of Independence (part of the Spanish American wars of independence), Venezuela initially won independence from the Spanish Empire as part of Gran Colombia. Internal tensions led to the dissolution of Gran Colombia in 1830/31, with Venezuela declaring independence in 1811. For the rest of the nineteenth century, independent Venezuela saw a range of caudillos (strongmen) compete for power. Leading political figures include José Antonio Páez (a leading figure particularly 1829–1847), Antonio Guzmán Blanco (1870 - 1887) and Cipriano Castro (1899 - 1908).
In a succession of rebellions, the Federal War (1858 - 1863) was particularly bloody, and saw the establishment of the modern system of States of Venezuela (replacing the Provinces of Venezuela largely inherited from the colonial era). The turn of the century saw several notable international crises which contributed to the development of the United States' Monroe Doctrine: the Venezuela Crisis of 1895 under Joaquín Crespo (regarding a dispute with Britain over Guayana Esequiba) and the Venezuela Crisis of 1902–1903 (regarding Venezuela's refusal to pay foreign debts) under Cipriano Castro.
Contrary to popular belief, Venezuela in the 19th century following independence did not experience one continuous civil war during which one caudillo followed another without rhyme or reason, the victors liquidating the defeated as a matter of course. As in human affairs everywhere, patterns of political ascendancy, downfalls, and resurgences developed. The same geographical reasons that had made possible the formation of Venezuela as a distinct national entity separate from New Granada during the colonial period, also made Venezuela a country difficult to govern. Venezuela had various regions: the Andes, the plains that stretched from the borders with New Granada to the Orinoco delta, Guayana, the Maracaibo basin, the Coro region, the Barquisimeto region, and central Venezuela, formed by the Caracas-Valencia axis and its surrounding areas. The llanos themselves comprised different sub-regions: the eastern part which included the Cumaná region (and the island of Margarita by extension), the Apure llanos, and the central and western llanos. Except for the llanos, where there were no geographical barriers between them, the other regions were separated from each other by either outright mountain ranges or rough mountainous terrains. The distinction between the eastern, central and western llanos was due to political precedents and circumstances. The eastern llanos and Guayana, had practically fought their own war of independence within the wider war of independence. They also had outlets to the sea. The central and western llanos, which politically were considered extensions of Caracas (except Barinas), had varying access to the central region. The Apure llanos were a prolongation of the central llanos. The western llanos, with the capital in Barinas, had been a province separate from Caracas, but they were in effect (the same as Apure) part of the same social, military, and political landscape.