The song was written by Queen guitarist Brian May, who intended to record it for his then-upcoming solo album Back to the Light (1992), but when he heard Queen lead singer Freddie Mercury sing the track, he allowed it to become a Queen song. As with all the songs on Innuendo, the track was promptly credited to the entire band.

The song was the first single to be released in the United States under their contract with Hollywood Records on 14 January 1991, though it was not released in the United Kingdom for another four months (the first single in the United Kingdom was "Innuendo", which Hollywood eventually released in the US as a promotional single for radio stations). The song charted on the Hot Mainstream Rock Tracks chart in the United States at #3. The line "And you're rushin' headlong" from the chorus is somewhat lifted from the second verse of "Breakthru", a single from Queen's previous album The Miracle, which contains the lyrics "I wanna rush headlong into this ecstasy".

The cover of one of the CD singles is inspired by Grandville illustrations, as are all of the other singles from the album.

"Headlong" was the third single release from the album Innuendo in the band's native country, the UK. Released in May 1991, it entered inside the UK singles chart Top 30 in its first week and the following week, peaked at no.14. It was the second highest charting song, off of the album, after the song "Innuendo", which reached the top of the charts.

The music video for "Headlong" was one of the final Queen videos shot with lead singer Freddie Mercury, some 12 months before his death from AIDS, though it was actually shot before the "I'm Going Slightly Mad" video (released as the second single in the UK). The video showed the band in the studio performing the song (in a stage-like setup), as well as shots of the band working in the studio. The version of the song in the video includes an extra short section after the second chorus not released in any audio format to date.

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