Haptoglobin

HP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4X0L, 4WJG, 5HU6
Identifiers
Aliases	HP, BP, HP2ALPHA2, HPA1S, haptoglobin
External IDs	OMIM: 140100 MGI: 96211 HomoloGene: 121756 GeneCards: HP
Gene ontology Molecular function • antioxidant activity • protein binding • hemoglobin binding Cellular component • extracellular region • endocytic vesicle lumen • extracellular exosome • blood microparticle • haptoglobin-hemoglobin complex • extracellular space • specific granule lumen • tertiary granule lumen Biological process • cellular oxidant detoxification • defense response • positive regulation of cell death • acute-phase response • receptor-mediated endocytosis • defense response to bacterium • response to hydrogen peroxide • negative regulation of oxidoreductase activity • negative regulation of hydrogen peroxide catabolic process • immune system process • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3240	15439
Ensembl	ENSG00000257017	ENSMUSG00000031722
UniProt	P00738	Q61646
RefSeq (mRNA)	NM_001126102 NM_005143 NM_001318138	NM_017370 NM_001329965
RefSeq (protein)	NP_001119574 NP_001305067 NP_005134	NP_059066.1 NP_001316894 NP_059066
Location (UCSC)	Chr 16: 72.05 – 72.06 Mb	Chr 8: 109.58 – 109.58 Mb
PubMed search

4X0L, 4WJG, 5HU6

3240

15439

ENSG00000257017

ENSMUSG00000031722

P00738

Q61646

NM_001126102
NM_005143
NM_001318138

NM_017370
NM_001329965

NP_001119574
NP_001305067
NP_005134

NP_059066.1
NP_001316894
NP_059066

Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the HP gene. In blood plasma, haptoglobin binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen).

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