"Hail Mary" is the final single by American rapper Tupac Shakur from his final album The Don Killuminati: The 7 Day Theory, under the new stage name, Makaveli. The song, released after his September 1996 death, features rap verses by Kastro, Young Noble and Yaki Kadafi of The Outlawz and Prince Ital Joe. A music video was shot for the song and can be found on the DualDisc of The Don Killuminati: The 7 Day Theory. It is one of Shakur's most famous singles. The single peaked at number 12 in the R&B chart, and number 8 in the rap singles.

The song captures Makaveli zoning out the violence and negativity surrounding him, praying to God, and making biblical references. "Hail Mary" appeared on Shakur's Greatest Hits in 1998. A remix of the song was also featured on the album Nu-Mixx Klazzics in 2003.

"Hail Mary" took under 1 hour to complete. It took about 15 minutes to write it and it took about five minutes to lay it. Hurt-M-Badd made the beat in 20–30 minutes. "Outlawz on a paper chase, can you relate?..." was originally going to be the hook but then Makaveli said "Nah, we going to put that at the end." Someremark that this song contains his deepest verses and proved his ability to write powerful lyrics.

This song was played as a tribute to 2Pac at the Up in Smoke Tour, in 2000. Rap artists Dr. Dre & Snoop Dogg played this song as one of 3 songs they did, for and a tribute to 2Pac, with the crowd singing the chorus.

On April 15, 2012, this song was played as the opening of the 2Pac Hologram's performance alongside live performers Dr. Dre and Snoop Dogg at the Coachella Valley Music and Arts Festival. The track moved 13,000 downloads that week for a 1,530% sales increase.

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