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HRH2

HRH2
Identifiers
Aliases HRH2, H2R, histamine receptor H2
External IDs MGI: 108482 HomoloGene: 40613 GeneCards: HRH2
Targeted by Drug
amthamine, impromidine, cimetidine, ciproxifan, clobenpropit, conessine, , pitolisant, , abt-239
RNA expression pattern
PBB GE HRH2 220805 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001131055
NM_022304

NM_001010973
NM_008286

RefSeq (protein)

NP_001124527
NP_071640

NP_001010973.1
NP_032312.2
NP_001010973
NP_032312

Location (UCSC) Chr 5: 175.66 – 175.71 Mb Chr 13: 54.19 – 54.24 Mb
PubMed search

NM_001131055
NM_022304

NM_001010973
NM_008286

NP_001124527
NP_071640

NP_001010973.1
NP_032312.2
NP_001010973
NP_032312

H2 receptors are positively coupled to adenylate cyclase via Gs. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. PKA functions to phosphorylate certain proteins, affecting their activity. The drug betazole is an example of a histamine H2 receptor agonist.


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Wikipedia

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