HRH2

HRH2
Identifiers
Aliases	HRH2, H2R, histamine receptor H2
External IDs	MGI: 108482 HomoloGene: 40613 GeneCards: HRH2
Targeted by Drug
amthamine, impromidine, cimetidine, ciproxifan, clobenpropit, conessine, , pitolisant, , abt-239
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • histamine receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • visual learning • G-protein coupled receptor signaling pathway • epithelial cell morphogenesis • gastric acid secretion • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • memory • toxin transport • regulation of synaptic plasticity • gastrin-induced gastric acid secretion • positive regulation of vasoconstriction • immune response • digestive tract development • signal transduction • gland development • histamine-induced gastric acid secretion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3274	15466
Ensembl	ENSG00000113749	ENSMUSG00000034987
UniProt	P25021	P97292
RefSeq (mRNA)	NM_001131055 NM_022304	NM_001010973 NM_008286
RefSeq (protein)	NP_001124527 NP_071640	NP_001010973.1 NP_032312.2 NP_001010973 NP_032312
Location (UCSC)	Chr 5: 175.66 – 175.71 Mb	Chr 13: 54.19 – 54.24 Mb
PubMed search

3274

15466

ENSG00000113749

ENSMUSG00000034987

P25021

P97292

NM_001131055
NM_022304

NM_001010973
NM_008286

NP_001124527
NP_071640

NP_001010973.1
NP_032312.2
NP_001010973
NP_032312

H₂ receptors are positively coupled to adenylate cyclase via G_s. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. PKA functions to phosphorylate certain proteins, affecting their activity. The drug betazole is an example of a histamine H₂ receptor agonist.

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Wikipedia