HPGD

HPGD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GDZ
Identifiers
Aliases	HPGD, 15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1, hydroxyprostaglandin dehydrogenase 15-(NAD), 15-hydroxyprostaglandin dehydrogenase
External IDs	MGI: 108085 HomoloGene: 68095 GeneCards: HPGD
Gene location (Human) Chr. Chromosome 4 (human) Band 4q34.1 Start 174,490,177 bp End 174,523,154 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band n/a Start 56,294,585 bp End 56,321,043 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • NAD binding • 15-hydroxyprostaglandin dehydrogenase (NAD+) activity • catalytic activity • prostaglandin E receptor activity • NAD+ binding • oxidoreductase activity • protein homodimerization activity Cellular component • nucleoplasm • basolateral plasma membrane • extracellular exosome • cytoplasm • cytosol • extracellular space Biological process • prostaglandin metabolic process • thrombin-activated receptor signaling pathway • lipid metabolic process • negative regulation of cell cycle • fatty acid metabolic process • lipoxygenase pathway • parturition • lipoxin metabolic process • oxidation-reduction process • transforming growth factor beta receptor signaling pathway • ovulation • ductus arteriosus closure • response to lipopolysaccharide • kidney development • female pregnancy • response to estradiol • positive regulation of apoptotic process • response to ethanol • positive regulation of vascular smooth muscle cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3248	15446
Ensembl	ENSG00000164120	ENSMUSG00000031613
UniProt	P15428	Q8VCC1
RefSeq (mRNA)	NM_000860 NM_001145816 NM_001256301 NM_001256305 NM_001256306 NM_001256307	NM_008278
RefSeq (protein)	NP_000851 NP_001139288 NP_001243230 NP_001243234 NP_001243235 NP_001243236	NP_032304
Location (UCSC)	Chr 4: 174.49 – 174.52 Mb	Chr 4: 56.29 – 56.32 Mb
PubMed search

2GDZ

3248

15446

ENSG00000164120

ENSMUSG00000031613

P15428

Q8VCC1

NM_001256307

NM_008278

NP_001243236

NP_032304

Hydroxyprostaglandin dehydrogenase 15-(NAD) (the HUGO-approved official symbol = HPGD; HGNC ID, HGNC:5154), also called 15-hydroxyprostaglandin dehydrogenase [NAD+], is an enzyme that in humans is encoded by the HPGD gene.

In melanocytic cells HPGD gene expression may be regulated by MITF.

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