HOXD13

HOXD13
Identifiers
Aliases	HOXD13, BDE, BDSD, HOX4I, SPD, SPD1, homeobox D13
External IDs	MGI: 96205 HomoloGene: 20147 GeneCards: HOXD13
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding Cellular component • nucleus Biological process • pattern specification process • skeletal system development • regulation of branching involved in prostate gland morphogenesis • male genitalia development • regulation of transcription, DNA-templated • limb morphogenesis • embryonic digit morphogenesis • embryonic hindgut morphogenesis • branch elongation of an epithelium • transcription, DNA-templated • multicellular organism development • gland morphogenesis • regulation of cell proliferation • embryonic limb morphogenesis • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis • anterior/posterior pattern specification • positive regulation of transcription from RNA polymerase II promoter • morphogenesis of an epithelial fold • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3239	15433
Ensembl	ENSG00000128714	ENSMUSG00000001819
UniProt	P35453	P70217
RefSeq (mRNA)	NM_000523	NM_008275
RefSeq (protein)	NP_000514	NP_032301.2 NP_032301
Location (UCSC)	Chr 2: 176.09 – 176.1 Mb	Chr 2: 74.67 – 74.67 Mb
PubMed search

3239

15433

ENSG00000128714

ENSMUSG00000001819

P35453

P70217

NM_000523

NM_008275

NP_000514

NP_032301.2
NP_032301

Homeobox protein Hox-D13 is a protein that in humans is encoded by the HOXD13 gene.

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly and Brachydactyly. The product of the mouse Hoxd13 gene plays a role in axial skeleton development and forelimb morphogenesis.

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Wikipedia