HOTAIR

Identifiers

Aliases

HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072, HOX transcript antisense RNA

External IDs

GeneCards: HOTAIR

Orthologs

Species

Human

Mouse

Entrez


100124700


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Ensembl


ENSG00000228630


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UniProt


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RefSeq (mRNA)


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RefSeq (protein)


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Location (UCSC)

Chr 12: 53.96 – 53.97 Mb

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PubMed search

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100124700

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ENSG00000228630

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HOTAIR (for HOX transcript antisense RNA) is a human gene located on chromosome 12. It is the first example of an RNA expressed on one chromosome that has been found to influence transcription on another chromosome.

The HOTAIR gene contains 6,232 bp and encodes 2.2 kb long noncoding RNA molecule, which controls gene expression. Its source DNA is located within a HOXC gene cluster. It is shuttled from chromosome 12 to chromosome 2 by the Suz-Twelve protein.

The 5' end of HOTAIR interacts with a Polycomb-group protein Polycomb Repressive Complex 2 (PRC2) and as a result regulates chromatin state. It is required for gene-silencing of the HOXD locus by PRC2. The 3' end of HOTAIR interacts with the histone demethylase LSD1.

It is an important factor in the epigenetic differentiation of skin over the surface of the body. Skin from various anatomical positions is distinct, e.g. the skin of the eyelid differs markedly from that on the sole of the foot.

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Wikipedia