HLA-DQ9
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HLA-DQ9
(MHC Class II, DQ cell surface antigen) |
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| Illustration of HLA-DQ with bound peptide. | |||
| Cis-haplotype | Haplotype | ||
| isoform, | subtype | DQA1 | DQB1 |
| DQ α2β9 | DQ9.2 | *0201 | *0303 |
| DQ α3β9 | DQ9.3 | *0302 | *0303 |
HLA-DQ9 (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ9 is a of the DQ3 . DQ9 is determined by the antibody recognition of β9 and this generally detects the gene product of DQB1*0303.
The serotyping efficiency of DQ9 is poor. The recognition of DQB1*0303 by DQ9 and or DQ3 is poorest, DQ2 which recognizes a different DQB1 subgroup recognizes DQB1*0303 as efficiently as DQ3. For this reason DQ9 serotyping is a poor method of typing for transplantation or disease association prediction or study.
(DQ9) is associated with nasal polyps,gestational diabetes, microscopic polyangiitis (Japanese). Primary linkage is with DRB1*0901-DQB1*0303
DQA1*0201:DQB1*0303 is associated with type I psoriasis (vulgaris),
DQA1*0302:DQB1*0303 maybe associated with juvenile diabetes in the orient. (Chinese) Primary linkage of vitiligo is with DQA1*03-DQB1*0303
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