HER2

ERBB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3N85, 3PP0, 3RCD, 3MZW, 3WLW, 3WSQ, 4GFU, 4HRL, 4HRM, 4HRN, 2N2A
Identifiers
Aliases	ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2
External IDs	OMIM: 164870 MGI: 95410 HomoloGene: 3273 GeneCards: ERBB2
EC number	2.7.10.1
Targeted by Drug
afatinib, canertinib, dacomitinib anhydrous, lapatinib, mubritinib, neratinib
Gene ontology Molecular function • ErbB-3 class receptor binding • transferase activity • nucleotide binding • protein kinase activity • signal transducer, downstream of receptor, with protein tyrosine kinase activity • protein dimerization activity • growth factor binding • RNA polymerase I core binding • kinase activity • protein C-terminus binding • protein binding • identical protein binding • protein heterodimerization activity • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • protein phosphatase binding • ATP binding • transmembrane signaling receptor activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • integral component of membrane • membrane • myelin sheath • receptor complex • plasma membrane • basolateral plasma membrane • apical plasma membrane • perinuclear region of cytoplasm • endosome membrane • cytoplasmic vesicle • nucleus • cytoplasm • cytosol Biological process • positive regulation of protein phosphorylation • peripheral nervous system development • regulation of transcription, DNA-templated • negative regulation of immature T cell proliferation in thymus • positive regulation of MAP kinase activity • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of epithelial cell proliferation • cellular response to growth factor stimulus • wound healing • oligodendrocyte differentiation • regulation of angiogenesis • positive regulation of translation • transcription, DNA-templated • nervous system development • MAPK cascade • protein phosphorylation • heart development • cell surface receptor signaling pathway • positive regulation of GTPase activity • positive regulation of cell growth • regulation of microtubule-based process • neuromuscular junction development • regulation of ERK1 and ERK2 cascade • myelination • protein autophosphorylation • phosphatidylinositol 3-kinase signaling • positive regulation of transcription from RNA polymerase I promoter • cell proliferation • positive regulation of transcription from RNA polymerase III promoter • motor neuron axon guidance • enzyme linked receptor protein signaling pathway • phosphatidylinositol-mediated signaling • signal transduction • positive regulation of cell adhesion • positive regulation of protein targeting to membrane • ERBB2 signaling pathway • phosphatidylinositol phosphorylation • positive regulation of gene expression • peptidyl-tyrosine phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • regulation of cell motility • cellular response to epidermal growth factor stimulus • regulation of transcription from RNA polymerase II promoter • negative regulation of ERBB signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2064	13866
Ensembl	ENSG00000141736	ENSMUSG00000062312
UniProt	P04626	P70424
RefSeq (mRNA)	NM_001005862 NM_001289936 NM_001289937 NM_001289938 NM_004448	NM_001003817
RefSeq (protein)	NP_001005862 NP_001276865 NP_001276866 NP_001276867 NP_004439	NP_001003817.1 NP_001003817
Location (UCSC)	Chr 17: 39.69 – 39.73 Mb	Chr 11: 98.41 – 98.44 Mb
PubMed search

1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3N85, 3PP0, 3RCD, 3MZW, 3WLW, 3WSQ, 4GFU, 4HRL, 4HRM, 4HRN, 2N2A

2064

13866

ENSG00000141736

...
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