Guzamn is one of the woredas in the Amhara Region of Ethiopia. Part of the Misraq Gojjam Zone, Guzamn is bordered on the southeast by Baso Liben, on the south by the Abay River which separates it from the Oromia Region, on the west by Debre Elias, on the northwest by Machakel, on the north by Sinan, and on the east by Aneded; the Chamwaga River defines part of the border between Guzamn and Baso Liben. The town and woreda of Debre Marqos is an enclave inside Guzamn. Towns in Guzamn include Chemoga and Yebokile. Sinan woreda was separate from Guzamn.
Landmarks include the fortified mountaintops of Jebelli and Mutera, which was used as a stronghold of the rulers of Gojjam until Birru Goshu was defeated and captured by Kassa Hailu (later known as Tewodros II) in the Battle of Amba Jebelli.
Based on the 2007 national census conducted by the Central Statistical Agency of Ethiopia (CSA), this woreda has a total population of 132,883, of whom 66,348 are men and 66,535 women; 2,584 or 1.94% are urban inhabitants. With an area of 1,173.80 square kilometers, Guzamn has a population density of 113.21, which is less than the Zone average of 153.8 persons per square kilometer. A total of 30,180 households were counted in this woreda, resulting in an average of 4.4 persons to a household, and 29,565 housing units. The majority of the inhabitants practiced Ethiopian Orthodox Christianity, with 95.3% reporting that as their religion, while 4.66% of the population said they were Muslim. The majority of the inhabitants practiced Ethiopian Orthodox Christianity, with 99.97% reporting that as their religion.