Guerra de Titanes (2010) ("War of the Titans") was professional wrestling major show event produced by AAA, which took place on December 5, 2010, in the Auditorio Benito Juárez in Zapopan, Jalisco, Mexico. The event was the fourteenth Guerra de Titanes show promoted by AAA since 1997 and was headlined by a match for the AAA Mega Championship between champion Dr. Wagner Jr. and challenger El Zorro. The main event of the evening saw Los Perros del Mal handing Los Psycho Circus their first ever loss, ending their three-year-long undefeated streak.

Starting in 1997 the Mexican professional wrestling, company AAA has held a major wrestling show late in the year, either November or December, called Guerra de Titanes ("War of the Titans"). The show often features championship matches or Lucha de Apuestas or bet matches where the competitors risked their wrestling mask or hair on the outcome of the match. In Lucha Libre the Lucha de Apuetas match is considered more prestigious than a championship match and a lot of the major shows feature one or more Apuesta matches. The Guerra de Titanes show is hosted by a new location each year, emanating from cities such as Madero, Chihuahua, Chihuahua, Mexico City, Guadalajara, Jalisco and more. The 2010 Guerra de Titanes show was the thirteenth show in the series.

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