The Guayana Region is an administrative region of eastern Venezuela.
The region has a population of 1,383,297 inhabitants and a territory of 458,344 km2, slightly over half the area of the whole country.
During the colonial period, it was known as Spanish Guiana. It borders the independent nation of Guyana (formerly British Guiana), and French Guinea, which form The Guianas.
Geologically it is part of the Guiana Shield, and is also known as the Venezuelan Guayana. The higher elevation Guayana Highlands and its tepuis (mesas) are in the southwestern section.
The region comprises three of the federal States of Venezuela: