Grigore Alexandru Ghica or Ghika (1803 or 1807 – 24 August 1857) was a Prince of Moldavia between 14 October 1849, and June 1853, and again between 30 October 1854, and 3 June 1856. His wife was Helena, a member of the Sturdza family and daughter of Ioan Sturdza, who had been Prince of Moldavia from 1822 to 1828.
Born sometime between 1800 and 1810, Grigore Alexandru was a member of the Ghica family of boyars, and a descendant of Phanariotes. After being educated in France and the German Confederation, he returned to his native country and rallied with the nationalist and liberal opposition to Prince Mihail Sturdza under the Regulamentul Organic regime. Following the 1848 Revolution and Sturdza's deposition, despite his political choices, with Russia's approval, the Moldavian Divan appointed Ghica as ruler for a seven-year term (recognition from the Ottoman Empire, the country's other overseer, was obtained through the Convention of Balta Liman).
Soon after receiving the throne in Iaşi, Ghica carried out a series of moderate reforms, and prepared to implement more radical ones. He was responsible for creating a corps of Gendarmes (3 April 1850), which was to serve as an embryo for the present-day Romanian Gendarmerie. In 1851, he nominated the Transylvanian-born intellectual August Treboniu Laurian, himself a noted supporter of ethnic Romanian nationalism, as Inspector of the Schools in Moldavia. Additionally, his rule relaxed censorship, and became noted for an increase in literary activities.