Granulin

GRN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G26, 2JYE, 2JYT, 2JYU, 2JYV
Identifiers
Aliases	GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGranulin, granulin precursor
External IDs	MGI: 95832 HomoloGene: 1577 GeneCards: GRN
Gene location (Human) Chr. Chromosome 17 (human) Band No data available Start 44,345,086 bp End 44,353,102 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band No data available Start 102,430,315 bp End 102,437,048 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine activity • growth factor activity • protein binding • RNA binding Cellular component • extracellular exosome • extracellular region • extracellular space • lysosome • endosome • endoplasmic reticulum • azurophil granule lumen Biological process • signal transduction • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2896	14824
Ensembl	ENSG00000030582	ENSMUSG00000034708
UniProt	P28799	P28798
RefSeq (mRNA)	NM_001012479 NM_002087	NM_008175
RefSeq (protein)	NP_002078	n/a
Location (UCSC)	Chr 17: 44.35 – 44.35 Mb	Chr 17: 102.43 – 102.44 Mb
PubMed search

Granulin
the solution structure of a well-folded peptide based on the 31-residue amino-terminal subdomain of human granulin a
Identifiers
Symbol	Granulin
Pfam	PF00396
InterPro	IPR000118
PROSITE	PDOC00634
SCOP	1pcn
SUPERFAMILY	1pcn
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

1G26, 2JYE, 2JYT, 2JYU, 2JYV

2896

14824

ENSG00000030582

ENSMUSG00000034708

P28799

P28798

NM_001012479
NM_002087

NM_008175

NP_002078

n/a

Granulin is a protein that in humans is encoded by the GRN gene.

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and prostate cancer (PC) cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively.