Graf1

ARHGAP26
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UGV
Identifiers
Aliases	ARHGAP26, GRAF, GRAF1, OPHN1L, OPHN1L1, Rho GTPase activating protein 26
External IDs	MGI: 1918552 HomoloGene: 36349 GeneCards: ARHGAP26
Gene ontology Molecular function • protein binding • phospholipid binding • GTPase activator activity Cellular component • cytoplasm • cytosol • cell junction • cytoskeleton • focal adhesion Biological process • regulation of small GTPase mediated signal transduction • actin cytoskeleton organization • nervous system development • signal transduction • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23092	71302
Ensembl	ENSG00000145819	ENSMUSG00000036452
UniProt	Q9UNA1	Q6ZQ82
RefSeq (mRNA)	NM_001135608 NM_015071 NM_001349547	NM_175164
RefSeq (protein)	NP_001129080 NP_055886 NP_001336476	NP_780373.3 NP_780373
Location (UCSC)	Chr 5: 142.77 – 143.23 Mb	Chr 18: 38.6 – 39.38 Mb
PubMed search

1UGV

23092

71302

ENSG00000145819

ENSMUSG00000036452

Q9UNA1

Q6ZQ82

NM_001135608
NM_015071
NM_001349547

NM_175164

NP_001129080
NP_055886
NP_001336476

NP_780373.3
NP_780373

Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a protein that in humans is encoded by the ARHGAP26 gene.

GRAF1 is a multidomain protein that is necessary for the CLIC/GEEC endocytic pathway. By virtue of an N-terminal BAR domain, GRAF1 sculpts the endocytic membranes of this pathway into 40 nm diameter tubules and vesicles that allow uptake of extracellular fluid, GPI-linked proteins and certain bacterial exotoxins into cells. The role of dynamin in the CLIC/GEEC pathway is controversial, but GRAF1 interacts strongly with this protein and acute inhibition of dynamin action abrogates CLIC/GEEC endocytosis. There are several members of the GRAF family of proteins, including GRAF2, GRAF3, and oligophrenin, all of which likely playing similar roles during clathrin-independent endocytic events. Mutations of both GRAF1 and oligophrenin are strongly implicated in causing human disease (leukaemia and mental retardation, respectively). Recently, autoantibodies to ARHGAP26 have been implicated in autoimmune cerebellar ataxia.

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Wikipedia