Glycine transporter 1

SLC6A9
Identifiers
Aliases	SLC6A9, GLYT1, Glycine transporter 1, solute carrier family 6 member 9, GCENSG
External IDs	MGI: 95760 HomoloGene: 5050 GeneCards: SLC6A9
Gene ontology Molecular function • neurotransmitter:sodium symporter activity • sodium:amino acid symporter activity • glycine transmembrane transporter activity • symporter activity • glycine:sodium symporter activity • transporter activity Cellular component • integral component of membrane • plasma membrane • membrane • presynapse • integral component of plasma membrane Biological process • amino acid transmembrane transport • neurotransmitter transport • amino acid transport • glycine secretion, neurotransmission • glycine transport • organic acid transmembrane transport • transmembrane transport • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6536	14664
Ensembl	ENSG00000196517	ENSMUSG00000028542
UniProt	P48067	P28571
RefSeq (mRNA)	NM_001024845 NM_001261380 NM_006934 NM_201649 NM_001328626 NM_001328627 NM_001328628 NM_001328629 NM_001328630	NM_008135
RefSeq (protein)	NP_001020016 NP_001248309 NP_001315555 NP_001315556 NP_001315557 NP_001315558 NP_001315559 NP_008865 NP_964012	NP_032161
Location (UCSC)	Chr 1: 43.99 – 44.03 Mb	Chr 4: 117.83 – 117.88 Mb
PubMed search

6536

14664

ENSG00000196517

ENSMUSG00000028542

P48067

P28571

NM_001328627
NM_001328628
NM_001328629
NM_001328630

NM_008135

NP_001315558
NP_001315559
NP_008865
NP_964012

NP_032161

Sodium- and chloride-dependent glycine transporter 1 is a protein that in humans is encoded by the SLC6A9 gene.

Elevation of extracellular synaptic glycine concentration by blockade of GlyT1 has been hypothesized to potentiate NMDA receptor function in vivo and to represent a rational approach for the treatment of schizophrenia and cognitive disorders. Several drug candidates have reached clinical trials.

...
Wikipedia