Gli3

GLI3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BLD
Identifiers
Aliases	GLI3, ACLS, GCPS, GLI3-190, GLI3FL, PAP-A, PAPA, PAPA1, PAPB, PHS, PPDIV, GLI family zinc finger 3
External IDs	OMIM: 165240 MGI: 95729 HomoloGene: 139 GeneCards: GLI3
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • histone deacetylase binding • RNA polymerase II regulatory region sequence-specific DNA binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • beta-catenin binding • chromatin binding • protein binding • histone acetyltransferase binding • nucleic acid binding • DNA binding • sequence-specific DNA binding Cellular component • cytoplasm • cytosol • transcriptional repressor complex • nucleus • nuclear speck • cell projection • mediator complex • cilium • axoneme • nucleoplasm • ciliary base • ciliary tip Biological process • embryonic skeletal system morphogenesis • pattern specification process • lateral semicircular canal development • negative regulation of neuron differentiation • T cell differentiation in thymus • tongue development • nose morphogenesis • optic nerve morphogenesis • smoothened signaling pathway involved in ventral spinal cord interneuron specification • anatomical structure formation involved in morphogenesis • oligodendrocyte differentiation • hindgut morphogenesis • spinal cord dorsal/ventral patterning • thymocyte apoptotic process • mammary gland development • limb development • odontogenesis of dentin-containing tooth • positive regulation of chondrocyte differentiation • embryonic digestive tract morphogenesis • inner ear development • metanephros development • melanocyte differentiation • negative regulation of canonical Wnt signaling pathway • negative regulation of cell proliferation • regulation of apoptotic process • positive regulation of neuroblast proliferation • regulation of transcription, DNA-templated • limb morphogenesis • negative regulation of smoothened signaling pathway • kidney development • lung development • tube development • embryonic organ development • lateral ganglionic eminence cell proliferation • negative regulation of cell differentiation • embryonic digit morphogenesis • negative regulation of alpha-beta T cell differentiation • in utero embryonic development • transcription, DNA-templated • negative thymic T cell selection • positive regulation of transcription, DNA-templated • heart development • central nervous system development • telencephalon development • branching involved in ureteric bud morphogenesis • embryonic limb morphogenesis • neural tube development • positive regulation of protein import into nucleus • smoothened signaling pathway • camera-type eye development • spinal cord motor neuron differentiation • positive regulation of alpha-beta T cell differentiation • lambdoid suture morphogenesis • regulation of bone development • palate development • proximal/distal pattern formation • anatomical structure development • wound healing • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • response to estrogen • cerebral cortex radial glia guided migration • positive regulation of osteoblast differentiation • developmental growth • pallium development • mammary gland specification • frontal suture morphogenesis • anterior semicircular canal development • regulation of gene expression • negative regulation of transcription, DNA-templated • dorsal/ventral pattern formation • branching morphogenesis of an epithelial tube • embryonic digestive tract development • subpallium development • sagittal suture morphogenesis • forebrain dorsal/ventral pattern formation • protein processing • axon guidance • brain development • smoothened signaling pathway involved in dorsal/ventral neural tube patterning • forebrain radial glial cell differentiation • regulation of cell proliferation • smoothened signaling pathway involved in spinal cord motor neuron cell fate specification • layer formation in cerebral cortex • embryonic morphogenesis • artery development • cell differentiation involved in kidney development • regulation of cell differentiation • forebrain development • neuron fate commitment • hippocampus development • camera-type eye morphogenesis • anterior/posterior pattern specification • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • prostate gland development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2737	14634
Ensembl	ENSG00000106571	ENSMUSG00000021318
UniProt	P10071	Q61602
RefSeq (mRNA)	NM_000168	NM_008130
RefSeq (protein)	NP_000159	NP_032156
Location (UCSC)	Chr 7: 41.96 – 42.24 Mb	Chr 13: 15.46 – 15.73 Mb
PubMed search

4BLD

2737

14634

ENSG00000106571

ENSMUSG00000021318

P10071

Q61602

NM_000168

NM_008130

NP_000159

NP_032156

Zinc finger protein GLI3 is a protein that in humans is encoded by the GLI3 gene.

This gene encodes a protein that belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH1) gene expression. It is also thought to play a role during embryogenesis.

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