The German-speaking states in the early modern period (1500–1800) were divided politically and religiously. They all suffered greatly in the Thirty Years War (1618–1648). Catholic Austria and Lutheran Prussia were the major players.
The Holy Roman Empire was dominated by the House of Habsburg throughout the Early Modern period.
The German Renaissance, part of the Northern Renaissance, was a cultural and artistic movement that spread among German thinkers in the 15th and 16th centuries, which originated with the Italian Renaissance in Italy. This was a result of German artists who had traveled to Italy to learn more and become inspired by the Renaissance movement. Many areas of the arts and sciences were influenced, notably by the spread of humanism to the various German states and principalities. There were many advances made in the development of new techniques in the fields of architecture, the arts, and the sciences. This also marked the time within Germany of a rise of power, independent city states, and spread of Franciscan humanism.
The German Reformation initiated by Martin Luther leads to the German Peasants' War in 1524-1525. Luther, along with his colleague Philipp Melanchthon, emphasized this point in his plea for the Reformation at the Imperial Diet of 1529 amid charges of heresy, but the edict by the Diet of Worms (1521) prohibited all innovations. Meanwhile, in these efforts to retain the guise of a Catholic reformer as opposed to a heretical revolutionary, and to appeal to German princes with his religious condemnation of the peasant revolts backed up by the Doctrine of the Two Kingdoms, Luther's growing conservatism would provoke more radical reformers. At a religious conference with the Zwinglians in 1529, Melanchthon joined with Luther in opposing a union with Zwingli. With the protestation of the Lutheran princes at the Diet of Speyer (1529) and rejection of the Lutheran "Augsburg Confession" at Augsburg (1530), a separate Lutheran church finally emerged. In Northern Europe Luther appealed to the growing national consciousness of the German states because he denounced the Pope for involvement in politics as well as religion. Moreover, he backed the nobility, which was now justified to crush the Great Peasant Revolt of 1525 and to confiscate church property by Luther's Doctrine of the Two Kingdoms. This explains the attraction of some territorial princes to Lutheranism. However, the Elector of Brandenburg, Joachim I, blamed Lutheranism for the revolt and so did others. In Brandenburg, it was only under his successor Joachim II that Lutheranism was established, and the old religion was not formally extinct in Brandenburg until the death of the last Catholic bishop there, Georg von Blumenthal, who was Bishop of Lebus and sovereign Prince-Bishop of Ratzeburg. Though Charles V fought the Reformation, it is no coincidence either that the reign of his nationalistic predecessor Maximilian I saw the beginning of the Reformation. While the centralized states of western Europe had reached accords with the Vatican permitting them to draw on the rich property of the church for government expenditures, enabling them to form state churches that were greatly autonomous of Rome, similar moves on behalf of the Empire were unsuccessful so long as princes and prince bishops fought reforms to drop the pretension of the secular universal empire.