GTF2H5

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1YDL, 2JNJ, 5IY8, 5IY6, 5IY7, 5IVW, 5IY9

Identifiers

Aliases

GTF2H5, C6orf175, TFB5, TFIIH, TGF2H5, TTD, TTD-A, TTDA, bA120J8.2, TTD3, general transcription factor IIH subunit 5

External IDs

MGI: 107227 HomoloGene: 45635 GeneCards: GTF2H5

Gene ontology
Molecular function	• rDNA binding • protein binding
Cellular component	• nucleoplasm • nucleolus • core TFIIH complex • nucleus • transcription factor TFIID complex
Biological process	• termination of RNA polymerase I transcription • regulation of transcription, DNA-templated • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase II promoter • 7-methylguanosine mRNA capping • transcription from RNA polymerase II promoter • transcription, DNA-templated • cellular response to DNA damage stimulus • global genome nucleotide-excision repair • transcription elongation from RNA polymerase I promoter • cellular response to gamma radiation • rRNA processing • transcription-coupled nucleotide-excision repair • transcription initiation from RNA polymerase II promoter • nucleotide-excision repair, DNA incision • nucleotide-excision repair, preincision complex assembly • nucleotide-excision repair, DNA incision, 3'-to lesion • nucleotide-excision repair • nucleotide-excision repair, DNA incision, 5'-to lesion • nucleotide-excision repair, DNA duplex unwinding • DNA repair • nucleotide-excision repair, preincision complex stabilization
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


404672


66467

Ensembl


ENSG00000272047


ENSMUSG00000034345

UniProt


Q6ZYL4


Q8K2X8

RefSeq (mRNA)


NM_207118


NM_181392

RefSeq (protein)


NP_997001


NP_852057.2 NP_852057

Location (UCSC)

Chr 6: 158.17 – 158.2 Mb

Chr 17: 6.08 – 6.09 Mb

PubMed search

1YDL, 2JNJ, 5IY8, 5IY6, 5IY7, 5IVW, 5IY9

NP_852057.2
NP_852057

General transcription factor IIH subunit 5 is a protein that in humans is encoded by the GTF2H5 gene.

The GTF2H5(TTDA) gene encodes a small (71 amino acid) protein that stabilizes the multi-subunit transcription repair factor IIH(TFIIH). TFIIH plays a key role in a major DNA repair process, nucleotide excision repair (NER), by opening the DNA double helix after the initial recognition of damage in one strand. This step is followed by excision of the damaged region to generate a single-strand gap, and then repair synthesis, using the undamaged strand as template, to accurately fill in the gap. Disruption of the GTF2H5(TTDA) gene in a knockout mouse-model completely inactivates NER. In humans, mutation in any one of four genes can give rise to the trichothiodystrophy phenotype. These genes are TTDN1, XPB, XPD and GTF2H5(TTDA).

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