XPB

ERCC3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4ERN, 5IY9, 5IVW, 5IY7, 5IY8, 5IY6

Identifiers

Aliases

ERCC3, excision repair cross-complementation group 3, BTF2, GTF2H, RAD25, TFIIH, XPB, TTD2, ERCC excision repair 3, TFIIH core complex helicase subunit

External IDs

OMIM: 133510 MGI: 95414 HomoloGene: 96 GeneCards: ERCC3

Gene ontology
Molecular function	• protein C-terminus binding • nucleotide binding • GTP binding • ATP-dependent DNA helicase activity • protein kinase activity • ATPase activity • hydrolase activity • DNA-dependent ATPase activity • dATP binding • protein N-terminus binding • RNA polymerase II carboxy-terminal domain kinase activity • 3'-5' DNA helicase activity • ATP binding • damaged DNA binding • DNA binding • peptide binding • transcription factor binding • protein binding • helicase activity
Cellular component	• core TFIIH complex • nucleus • nucleoplasm • holo TFIIH complex • transcription factor TFIID complex
Biological process	• response to hypoxia • termination of RNA polymerase I transcription • embryonic organ development • transcription, DNA-templated • response to UV • 7-methylguanosine mRNA capping • nucleotide-excision repair, DNA incision • regulation of mitotic cell cycle phase transition • apoptotic process • positive regulation of apoptotic process • protein phosphorylation • hair cell differentiation • transcription elongation from RNA polymerase I promoter • response to oxidative stress • UV protection • cellular response to DNA damage stimulus • transcription initiation from RNA polymerase II promoter • global genome nucleotide-excision repair • protein localization • transcription elongation from RNA polymerase II promoter • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • DNA topological change • transcription initiation from RNA polymerase I promoter • transcription from RNA polymerase II promoter • transcription-coupled nucleotide-excision repair • nucleotide-excision repair • nucleotide-excision repair, preincision complex stabilization • nucleotide-excision repair, DNA duplex unwinding • DNA repair • viral process • nucleotide-excision repair, preincision complex assembly • nucleotide-excision repair, DNA incision, 5'-to lesion • nucleotide-excision repair, DNA incision, 3'-to lesion
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2071


13872

Ensembl


ENSG00000163161


ENSMUSG00000024382

UniProt


P19447


P49135

RefSeq (mRNA)


NM_000122 NM_001303416 NM_001303418


NM_133658

RefSeq (protein)


NP_000113 NP_001290345 NP_001290347


NP_598419.1 NP_598419

Location (UCSC)

Chr 2: 127.26 – 127.29 Mb

Chr 18: 32.24 – 32.27 Mb

PubMed search

4ERN, 5IY9, 5IVW, 5IY7, 5IY8, 5IY6

NM_000122
NM_001303416
NM_001303418

NM_133658

NP_000113
NP_001290345
NP_001290347

NP_598419.1
NP_598419

...
Wikipedia