GRIK5

GRIK5
Identifiers
Aliases	GRIK5, EAA2, GRIK2, GluK5, KA2, glutamate ionotropic receptor kainate type subunit 5
External IDs	MGI: 95818 HomoloGene: 1578 GeneCards: GRIK5
Genetically Related Diseases
bipolar disorder
Gene ontology Molecular function • glutamate receptor activity • PDZ domain binding • kainate selective glutamate receptor activity • SH3 domain binding • ion channel activity • ionotropic glutamate receptor activity • identical protein binding • extracellular-glutamate-gated ion channel activity • receptor activity • ligand-gated ion channel activity Cellular component • integral component of membrane • perikaryon • postsynaptic membrane • kainate selective glutamate receptor complex • membrane • postsynaptic density • plasma membrane • synapse • cell junction • terminal bouton • axon • dendrite • neuronal cell body • endoplasmic reticulum • neuron projection • ionotropic glutamate receptor complex • presynaptic membrane Biological process • synaptic transmission, glutamatergic • regulation of membrane potential • ion transport • receptor clustering • protein retention in ER lumen • regulation of synaptic vesicle fusion to presynaptic active zone membrane • ion transmembrane transport • positive regulation of neuron apoptotic process • establishment of localization in cell • ionotropic glutamate receptor signaling pathway • excitatory postsynaptic potential • transport • cellular response to glucose stimulus • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2901	14809
Ensembl	ENSG00000105737	ENSMUSG00000003378
UniProt	Q16478	Q61626
RefSeq (mRNA)	NM_001301030 NM_002088	NM_008168
RefSeq (protein)	NP_001287959 NP_002079	NP_032194.2 NP_032194
Location (UCSC)	Chr 19: 42 – 42.07 Mb	Chr 7: 25.01 – 25.07 Mb
PubMed search

2901

14809

ENSG00000105737

ENSMUSG00000003378

Q16478

Q61626

NM_001301030
NM_002088

NM_008168

NP_001287959
NP_002079

NP_032194.2
NP_032194

Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.

GRIK5 has been shown to interact with DLG4 and GRIK2.

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Wikipedia