GRIK2

GRIK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QXM, 5CMM
Identifiers
Aliases	GRIK2, EAA4, GLR6, GLUK6, GLUR6, GluK2, MRT6, glutamate ionotropic receptor kainate type subunit 2
External IDs	MGI: 95815 HomoloGene: 40717 GeneCards: GRIK2
Gene ontology Molecular function • glutamate receptor activity • PDZ domain binding • kainate selective glutamate receptor activity • protein homodimerization activity • ion channel activity • ionotropic glutamate receptor activity • identical protein binding • ubiquitin conjugating enzyme binding • ubiquitin protein ligase binding • receptor activity • ligand-gated ion channel activity • extracellular-glutamate-gated ion channel activity Cellular component • integral component of membrane • perikaryon • postsynaptic membrane • membrane • plasma membrane • synapse • integral component of plasma membrane • cell junction • terminal bouton • axon • dendrite • dendrite cytoplasm • ionotropic glutamate receptor complex Biological process • neuron apoptotic process • glutamate receptor signaling pathway • modulation of synaptic transmission • ion transport • receptor clustering • ion transmembrane transport • positive regulation of neuron apoptotic process • regulation of JNK cascade • ionotropic glutamate receptor signaling pathway • positive regulation of synaptic transmission • excitatory postsynaptic potential • transport • negative regulation of synaptic transmission, glutamatergic • chemical synaptic transmission • regulation of short-term neuronal synaptic plasticity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2898	14806
Ensembl	ENSG00000164418	ENSMUSG00000056073
UniProt	Q13002	P39087
RefSeq (mRNA)	NM_001166247 NM_021956 NM_175768	NM_001111268 NM_010349
RefSeq (protein)	NP_001159719 NP_068775 NP_786944	NP_001104738 NP_034479
Location (UCSC)	Chr 6: 101.4 – 102.07 Mb	Chr 10: 49.1 – 49.78 Mb
PubMed search

3QXM, 5CMM

2898

14806

ENSG00000164418

ENSMUSG00000056073

Q13002

P39087

NM_001166247
NM_021956
NM_175768

NM_001111268
NM_010349

NP_001159719
NP_068775
NP_786944

NP_001104738
NP_034479

Glutamate receptor, ionotropic kainate 2 is a protein that in humans is encoded by the GRIK2 gene.

This gene encodes a subunit of a kainate glutamate receptor. Glutamate receptors mediate the majority of excitatory neurotransmission in the brain. This receptor may have a role in synaptic plasticity and may be important for learning and memory. It also may be involved in the transmission of light information from the retina to the hypothalamus. The structure and function of the encoded protein is changed by RNA editing. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.

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