GPX2 (gene)

GPX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HE3
Identifiers
Aliases	GPX2, GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPX-GI, GSHPx-2, glutathione peroxidase 2
External IDs	MGI: 106609 HomoloGene: 20479 GeneCards: GPX2
Gene ontology Molecular function • electron carrier activity • oxidoreductase activity • glutathione peroxidase activity • peroxidase activity Cellular component • cytoplasm • cytosol • extracellular exosome Biological process • oxidation-reduction process • response to oxidative stress • response to reactive oxygen species • cellular oxidant detoxification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2877	14776
Ensembl	ENSG00000176153	ENSMUSG00000042808
UniProt	P18283	Q9JHC0
RefSeq (mRNA)	NM_002083	NM_030677
RefSeq (protein)	NP_002074	NP_109602.2 NP_109602
Location (UCSC)	Chr 14: 64.94 – 64.94 Mb	Chr 12: 76.79 – 76.8 Mb
PubMed search

2HE3

2877

14776

ENSG00000176153

ENSMUSG00000042808

P18283

Q9JHC0

NM_002083

NM_030677

NP_002074

NP_109602.2
NP_109602

Glutathione peroxidase 2 is an enzyme that in humans is encoded by the GPX2 gene.

This gene is a member of the glutathione peroxidase family encoding a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. Studies in knockout mice indicate that mRNA expression levels respond to luminal microflora, suggesting a role of the ileal glutathione peroxidases in preventing inflammation in the GI tract.

The antioxidant enzyme glutathione peroxidase 2 (Gpx2) is one out of eight known glutathione peroxidases (Gpx1-8) in humans. Mammalian Gpx1, GPx2 (this protein), Gpx3, and Gpx4 have been shown to be selenium-containing enzymes, whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents. In selenoproteins, the 21st amino acid selenocysteine is inserted in the nascent polypeptide chain during the process of translational recoding of the UGA stop codon.

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Wikipedia