GPX1

GPX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F8A
Identifiers
Aliases	GPX1, GPXD, GSHPX1, glutathione peroxidase 1
External IDs	MGI: 104887 HomoloGene: 20155 GeneCards: GPX1
Gene ontology Molecular function • peroxidase activity • SH3 domain binding • glutathione peroxidase activity • oxidoreductase activity Cellular component • cytoplasm • Lewy body • mitochondrial matrix • extracellular exosome • mitochondrion • cytosol Biological process • regulation of proteasomal protein catabolic process • intrinsic apoptotic signaling pathway in response to oxidative stress • myotube differentiation • response to selenium ion • positive regulation of protein kinase B signaling • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to xenobiotic stimulus • endothelial cell development • glutathione metabolic process • regulation of gene expression, epigenetic • blood vessel endothelial cell migration • lipid metabolic process • response to reactive oxygen species • negative regulation of release of cytochrome c from mitochondria • angiogenesis involved in wound healing • regulation of neuron apoptotic process • vasodilation • purine nucleotide catabolic process • negative regulation of apoptotic process • response to symbiotic bacterium • response to hydroperoxide • regulation of mammary gland epithelial cell proliferation • sensory perception of sound • response to oxidative stress • cell redox homeostasis • lipoxygenase pathway • positive regulation of supramolecular fiber organization • myoblast proliferation • skeletal muscle tissue regeneration • negative regulation of inflammatory response to antigenic stimulus • response to wounding • skeletal muscle fiber development • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • interaction with symbiont • UV protection • cellular response to oxidative stress • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • temperature homeostasis • cell proliferation • response to gamma radiation • triglyceride metabolic process • protein oxidation • response to toxic substance • fat cell differentiation • oxidation-reduction process • apoptotic process • cellular oxidant detoxification • response to hydrogen peroxide • hydrogen peroxide catabolic process • heart contraction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2876	14775
Ensembl	ENSG00000233276	ENSMUSG00000063856
UniProt	P07203	P11352
RefSeq (mRNA)	NM_201397 NM_000581	NM_008160
RefSeq (protein)	NP_000572 NP_001316384 NP_001316431 NP_001316432 NP_958799	NP_032186.2 NP_001316456 NP_001316457 NP_032186
Location (UCSC)	Chr 3: 49.36 – 49.36 Mb	Chr 9: 108.34 – 108.34 Mb
PubMed search

2F8A

2876

14775

ENSG00000233276

ENSMUSG00000063856

P07203

P11352

NM_201397
NM_000581

NM_008160

NP_000572
NP_001316384
NP_001316431
NP_001316432
NP_958799

NP_032186.2
NP_001316456
NP_001316457
NP_032186

Glutathione peroxidase 1, also known as GPx1, is an enzyme that in humans is encoded by the GPX1 gene on chromosome 3. This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans.

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Wikipedia