GPER

GPER1
Identifiers
Aliases	GPER1, Gper1, 6330420K13Rik, CMKRL2, Ceprl, FEG-1, GPCR-Br, Gper, Gpr30, CEPR, DRY12, LERGU, LERGU2, LyGPR, mER, G protein-coupled estrogen receptor 1
External IDs	MGI: 1924104 HomoloGene: 15855 GeneCards: GPER1
Targeted by Drug
17β-estradiol, tamoxifen
Gene ontology Molecular function • estrogen receptor activity • steroid hormone binding • chromatin binding • protein binding • signal transducer activity • mineralocorticoid receptor activity • steroid binding • G-protein coupled receptor activity Cellular component • cytoplasm • endosome • nuclear envelope • membrane • synapse • trans-Golgi network • mitochondrion • perinuclear region of cytoplasm • cytoskeleton • nucleus • cell projection • mitochondrial membrane • keratin filament • dendritic shaft • dendritic spine head • endoplasmic reticulum • dendritic spine membrane • integral component of membrane • recycling endosome • Golgi apparatus • plasma membrane • intracellular • presynaptic active zone • axon • early endosome • axon terminus • endoplasmic reticulum membrane • postsynaptic density • Golgi membrane • integral component of plasma membrane • cell junction • dendrite • cytoplasmic vesicle membrane • presynaptic membrane • cytoplasmic vesicle Biological process • positive regulation of protein phosphorylation • positive regulation of vasodilation • negative regulation of cell cycle arrest • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of G-protein coupled receptor protein signaling pathway • positive regulation of ERK1 and ERK2 cascade • positive regulation of extrinsic apoptotic signaling pathway • cell cycle • negative regulation of inflammatory response • cellular response to glucose stimulus • steroid hormone mediated signaling pathway • negative regulation of cell proliferation • apoptotic process • positive regulation of cAMP biosynthetic process • negative regulation of fat cell differentiation • negative regulation of leukocyte activation • apoptotic chromosome condensation • regulation of cytosolic calcium ion concentration • positive regulation of neurotransmitter secretion • negative regulation of gene expression • positive regulation of establishment of protein localization to plasma membrane • nuclear fragmentation involved in apoptotic nuclear change • positive regulation of endothelial cell apoptotic process • positive regulation of inositol trisphosphate biosynthetic process • positive regulation of cardiac vascular smooth muscle cell differentiation • innate immune response • inflammatory response • positive regulation of MAPK cascade • G-protein coupled receptor signaling pathway • negative regulation of protein kinase B signaling • cell differentiation • immune system process • negative regulation of cell cycle process • positive regulation of release of sequestered calcium ion into cytosol • negative regulation of lipid biosynthetic process • nervous system development • positive regulation of neurogenesis • positive regulation of release of cytochrome c from mitochondria • positive regulation of epidermal growth factor receptor signaling pathway • positive regulation of insulin secretion • negative regulation of vascular smooth muscle cell proliferation • positive regulation of cell migration • positive regulation of cytosolic calcium ion concentration • cellular response to tumor necrosis factor • cellular response to estradiol stimulus • cellular response to peptide hormone stimulus • positive regulation of gene expression • cellular response to mineralocorticoid stimulus • positive regulation of cell proliferation • negative regulation of ERK1 and ERK2 cascade • negative regulation of DNA metabolic process • positive regulation of transcription from RNA polymerase II promoter • positive regulation of uterine smooth muscle contraction • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway • neuronal action potential • signal transduction • mineralocorticoid receptor signaling pathway • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of apoptotic process • intracellular steroid hormone receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2852	76854
Ensembl	ENSG00000164850	ENSMUSG00000053647
UniProt	Q99527	Q8BMP4
RefSeq (mRNA)	NM_001031682 NM_001039966 NM_001098201 NM_001505	NM_029771
RefSeq (protein)	NP_001035055 NP_001091671 NP_001496	NP_084047.2 NP_084047
Location (UCSC)	Chr 7: 1.08 – 1.09 Mb	Chr 5: 139.42 – 139.43 Mb
PubMed search

2852

76854

ENSG00000164850

ENSMUSG00000053647

Q99527

Q8BMP4

NM_001031682
NM_001039966
NM_001098201
NM_001505

NM_029771

NP_001035055
NP_001091671
NP_001496

NP_084047.2
NP_084047

G protein-coupled estrogen receptor 1 (GPER), also known as G protein-coupled receptor 30 (GPR30), is a protein that in humans is encoded by the GPER gene. GPER binds to and is activated by the female sex hormone estradiol and is responsible for some of the rapid effects that estradiol has on cells.

The classical estrogen receptors first characterized in 1958 are water-soluble proteins located in the interior of cells that are activated by estrogenenic hormones such as estradiol and several of its metabolites such as estrone or estriol. These proteins belong to the nuclear hormone receptor class of transcription factors that regulate gene transcription. Since it takes time for genes to be transcribed into RNA and translated into protein, the effects of estrogens binding to these classical estrogen receptors is delayed. However, estrogens are also known to have effects that are too fast to be caused by regulation of gene transcription. In 2005, it was discovered that a member of the G protein-coupled receptor (GPCR) family, GPR30 also binds with high affinity to estradiol and is responsible in part for the rapid non-genomic actions of estradiol. Based on its ability to bind estradiol, GPR30 was renamed as G protein-coupled estrogen receptor (GPER). Unlike the other members of the GPCR family, which reside in the outer membrane of cells, GPER is localized in the endoplasmic reticulum.

...
Wikipedia