GLYCAM-1

glycosylation dependent cell adhesion molecule-1
Identifiers
Symbol	GLYCAM1
Entrez	644076
HUGO	18023
RefSeq	XM_927461
UniProt	Q8IVK1
Other data
Locus	Chr. 12 q13.2

Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymph nodes. It is able to bind to the receptor L-selectin during inflammation, acting as a homing beacon for leukocytes expressing the receptor to enter the site of inflammation. GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin. Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.

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