GLUD1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1L1F, 1NR1

Identifiers

GLUD1, GDH, GDH1, GLUD, glutamate dehydrogenase 1

External IDs

Gene ontology
Molecular function	• nucleotide binding • ADP binding • GTP binding • leucine binding • protein binding • NAD+ binding • identical protein binding • oxidoreductase activity • ATP binding • glutamate dehydrogenase [NAD(P)+ activity] • glutamate dehydrogenase (NAD+) activity
Cellular component	• cytoplasm • mitochondrial matrix • mitochondrion
Biological process	• glutamate catabolic process • glutamate biosynthetic process • substantia nigra development • cellular amino acid metabolic process • cellular amino acid biosynthetic process • glutamine metabolic process • tricarboxylic acid metabolic process • oxidation-reduction process • positive regulation of insulin secretion • mitochondrion organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2746


14661


ENSG00000148672


ENSMUSG00000021794


P00367


P26443

RefSeq (mRNA)

NM_005271 NM_001318900 NM_001318901 NM_001318902 NM_001318904
NM_001318905 NM_001318906


NM_008133

RefSeq (protein)

NP_001305829 NP_001305830 NP_001305831 NP_001305833 NP_001305834
NP_001305835 NP_005262


NP_032159

Location (UCSC)

PubMed search

GLUD1 (glutamate dehydrogenase 1) is a matrix enzyme, one of the family of glutamate dehydrogenases that are ubiquitous in life, with a key role in nitrogen and glutamate (Glu) metabolism and energy homeostasis. This dehydrogenase is expressed at high levels in liver, brain, pancreas and kidney, but not in muscle. In the pancreatic cells, GLUD1 is thought to be involved in insulin secretion mechanisms. In nervous tissue, where glutamate is present in concentrations higher than in the other tissues, GLUD1 appears to function in both the synthesis and the catabolism of glutamate and perhaps in ammonia detoxification.