GFRα1

GFRA1
Identifiers
Aliases	GFRA1, GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1, GDNF family receptor alpha 1
External IDs	MGI: 1100842 HomoloGene: 3855 GeneCards: GFRA1
Gene location (Human) Chr. Chromosome 10 (human) Band 10q25.3 Start 116,056,925 bp End 116,273,467 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 D2|19 54.18 cM Start 58,235,604 bp End 58,455,909 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor activity • receptor binding • glial cell-derived neurotrophic factor receptor activity • Ras guanyl-nucleotide exchange factor activity Cellular component • anchored component of membrane • extracellular exosome • membrane • extrinsic component of membrane • intracellular • plasma membrane Biological process • cell surface receptor signaling pathway • nervous system development • MAPK cascade • glial cell-derived neurotrophic factor receptor signaling pathway • axon guidance • regulation of molecular function Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2674	14585
Ensembl	ENSG00000151892	ENSMUSG00000025089
UniProt	P56159	P97785
RefSeq (mRNA)	NM_001145453 NM_005264 NM_145793 NM_001348096 NM_001348097 NM_001348098 NM_001348099	NM_001285457 NM_010279
RefSeq (protein)	NP_001138925 NP_005255 NP_665736 NP_001335025 NP_001335026 NP_001335027 NP_001335028	NP_001272386 NP_034409
Location (UCSC)	Chr 10: 116.06 – 116.27 Mb	Chr 10: 58.24 – 58.46 Mb
PubMed search

2674

14585

ENSG00000151892

ENSMUSG00000025089

P56159

P97785

NM_001348098
NM_001348099

NM_001285457
NM_010279

NP_001335027
NP_001335028

NP_001272386
NP_034409

GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene.

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

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Wikipedia