Glial cell line-derived neurotrophic factor

GDNF

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2V5E, 3FUB, 4UX8

Identifiers

Aliases

GDNF, ATF1, ATF2, HFB1-HSCR3, glial cell derived neurotrophic factor

External IDs

OMIM: 600837 MGI: 107430 HomoloGene: 433 GeneCards: GDNF

Gene ontology
Molecular function	• protein homodimerization activity • protein binding • growth factor activity • receptor binding • Ras guanyl-nucleotide exchange factor activity
Cellular component	• extracellular region • intracellular
Biological process	• peristalsis • ureteric bud development • regulation of dopamine uptake involved in synaptic transmission • peripheral nervous system development • sympathetic nervous system development • organ induction • adult locomotory behavior • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • regulation of stem cell differentiation • regulation of morphogenesis of a branching structure • mesenchymal to epithelial transition involved in metanephros morphogenesis • negative regulation of apoptotic process • nervous system development • positive regulation of monooxygenase activity • enteric nervous system development • mRNA stabilization • branching involved in ureteric bud morphogenesis • postganglionic parasympathetic fiber development • positive regulation of dopamine secretion • neural crest cell migration • postsynaptic membrane organization • positive regulation of cell proliferation • positive regulation of cell differentiation • positive regulation of ureteric bud formation • ureteric bud formation • regulation of gene expression • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • metanephros development • neuron projection development • signal transduction • positive regulation of transcription from RNA polymerase II promoter • MAPK cascade • positive regulation of GTPase activity • axon guidance • negative regulation of neuron apoptotic process • positive regulation of branching involved in ureteric bud morphogenesis
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2668


14573

Ensembl


ENSG00000168621


ENSMUSG00000022144

UniProt


P39905


P48540

RefSeq (mRNA)

NM_000514 NM_001190468 NM_001190469 NM_001278098 NM_199231
NM_199234


NM_010275 NM_001301332 NM_001301333 NM_001301357

RefSeq (protein)


NP_000505 NP_001177397 NP_001177398 NP_001265027 NP_954701

NP_001288261.1 NP_001288286.1 NP_034405.1 NP_001288261 NP_001288262
NP_001288286 NP_034405

Location (UCSC)

Chr 5: 37.81 – 37.84 Mb

Chr 15: 7.81 – 7.84 Mb

PubMed search

2V5E, 3FUB, 4UX8

NM_010275
NM_001301332
NM_001301333
NM_001301357

NP_000505
NP_001177397
NP_001177398
NP_001265027
NP_954701

NP_001288286
NP_034405

...
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