GFI1

Identifiers

GFI1, GFI-1, GFI1A, SCN2, ZNF163, growth factor independent 1 transcriptional repressor

External IDs

Gene ontology
Molecular function	• DNA binding • metal ion binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • nucleic acid binding • transcription regulatory region DNA binding
Cellular component	• nuclear body • nuclear matrix • transcriptional repressor complex • nucleus
Biological process	• hemopoiesis • positive regulation of interleukin-6-mediated signaling pathway • negative regulation of neuron projection development • regulation of transcription, DNA-templated • regulation of toll-like receptor signaling pathway • regulation of histone H3-K4 methylation • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription involved in G1/S transition of mitotic cell cycle • transcription, DNA-templated • negative regulation of vitamin D biosynthetic process • negative regulation of calcidiol 1-monooxygenase activity • viral process • negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • cellular response to lipopolysaccharide
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2672


14581


ENSG00000162676


ENSMUSG00000029275


Q99684


P70338

RefSeq (mRNA)


NM_001127215 NM_001127216 NM_005263


NM_001267621 NM_010278

RefSeq (protein)


NP_001120687 NP_001120688 NP_005254


NP_034408.1 NP_001254550 NP_034408

Location (UCSC)

PubMed search

Zinc finger protein Gfi-1 is a protein that in humans is encoded by the GFI1 gene.

GFI1 has been shown to interact with PIAS3 and RUNX1T1.