PIAS3

PIAS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MVT
Identifiers
Aliases	PIAS3, ZMIZ5, protein inhibitor of activated STAT 3
External IDs	MGI: 1913126 HomoloGene: 4447 GeneCards: PIAS3
Gene ontology Molecular function • protein N-terminus binding • zinc ion binding • metal ion binding • potassium channel regulator activity • ligase activity • protein C-terminus binding • protein binding • enzyme binding • SUMO transferase activity Cellular component • cytoplasm • nuclear speck • synapse • nucleoplasm • dendrite • nucleus Biological process • negative regulation of protein sumoylation • regulation of transcription, DNA-templated • positive regulation of protein sumoylation • protein sumoylation • transcription, DNA-templated • positive regulation of gene expression • response to hormone • positive regulation of membrane potential • regulation of molecular function Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10401	229615
Ensembl	ENSG00000131788	ENSMUSG00000028101
UniProt	Q9Y6X2	O54714
RefSeq (mRNA)	NM_006099	NM_001165949 NM_018812 NM_146135
RefSeq (protein)	NP_006090	NP_001159421 NP_061282 NP_666247
Location (UCSC)	Chr 1: 145.85 – 145.86 Mb	Chr 3: 96.7 – 96.71 Mb
PubMed search

4MVT

10401

229615

ENSG00000131788

ENSMUSG00000028101

Q9Y6X2

O54714

NM_006099

NM_001165949
NM_018812
NM_146135

NP_006090

NP_001159421
NP_061282
NP_666247

E3 SUMO-protein ligase PIAS3 is an enzyme that in humans is encoded by the PIAS3 gene.

The mammalian PIAS family consists of four members: PIAS1, PIAS2, PIAS3 and PIAS4. In Drosophila, a single PIAS homologue named dPIAS/Zimp has been identified. In yeast, two PIAS-related proteins were identified namely SIZ1 and SIZ2. The PIAS family contains more than 60 proteins, most of them transcription factors that can be either positively or negatively regulated through multiple mechanisms.

IAS proteins were originally identified in studies that were aimed to decipher the Janus Kinase (JAK)/STAT signaling pathway. Originally, PIAS3 was found to interact specifically with phosphorylated STAT3 in Interleukin -6 (IL-6) activated murine myeloblast M1 cells. This interaction is mediated via PIAS3 binding to the STAT3 DNA binding domain. Hence, STAT3 transcriptional activity is inhibited by the physical prevention of its binding to target genes. Subsequently, PIAS3 was also found to be a regulator protein of other key transcription factors, including MITF,NFκB,SMAD and estrogen receptor.

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Wikipedia