GEMIN4

GEMIN4
Identifiers
Aliases	GEMIN4, HC56, HCAP1, HHRF-1, p97, gem nuclear organelle associated protein 4
External IDs	MGI: 2449313 HomoloGene: 69193 GeneCards: GEMIN4
Gene ontology Molecular function • protein binding Cellular component • SMN-Sm protein complex • cytosol • nucleolus • small nuclear ribonucleoprotein complex • extracellular exosome • membrane • Gemini of coiled bodies • nucleoplasm • SMN complex • nucleus • cytoplasm • nuclear body Biological process • mRNA processing • RNA splicing • nuclear import • spliceosomal snRNP assembly • rRNA processing Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50628	276919
Ensembl	ENSG00000179409	ENSMUSG00000049396
UniProt	P57678	n/a
RefSeq (mRNA)	NM_015721	NM_177367
RefSeq (protein)	NP_056536	n/a
Location (UCSC)	Chr 17: 0.74 – 0.75 Mb	Chr 11: 76.21 – 76.22 Mb
PubMed search

50628

276919

ENSG00000179409

ENSMUSG00000049396

P57678

n/a

NM_015721

NM_177367

NP_056536

n/a

Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene.

The product of this gene is part of the SMN protein complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

GEMIN4 has been shown to interact with:

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Wikipedia