GDF11

GDF11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5E4G
Identifiers
Aliases	GDF11, BMP-11, BMP11, growth differentiation factor 11
External IDs	OMIM: 603936 MGI: 1338027 HomoloGene: 21183 GeneCards: GDF11
Gene ontology Molecular function • cytokine activity • transforming growth factor beta receptor binding • growth factor activity Cellular component • intracellular membrane-bounded organelle • nucleoplasm • protein complex • extracellular region • extracellular space Biological process • regulation of apoptotic process • skeletal system development • palate development • ureteric bud development • regulation of MAPK cascade • spinal cord anterior/posterior patterning • SMAD protein signal transduction • cell development • negative regulation of cell differentiation • positive regulation of pathway-restricted SMAD protein phosphorylation • cell maturation • nervous system development • animal organ morphogenesis • pancreas development • mesoderm development • metanephros development • camera-type eye morphogenesis • anterior/posterior pattern specification • negative regulation of cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10220	14561
Ensembl	ENSG00000135414	ENSMUSG00000025352
UniProt	O95390	Q9Z1W4
RefSeq (mRNA)	NM_005811	NM_010272
RefSeq (protein)	NP_005802	NP_034402.1 NP_034402
Location (UCSC)	Chr 12: 55.74 – 55.76 Mb	Chr 10: 128.88 – 128.89 Mb
PubMed search

5E4G

10220

14561

ENSG00000135414

ENSMUSG00000025352

O95390

Q9Z1W4

NM_005811

NM_010272

NP_005802

NP_034402.1
NP_034402

Growth differentiation factor 11 (GDF11) also known as bone morphogenetic protein 11 (BMP-11) is a protein that in humans is encoded by the GDF11 gene.

It acts as a cytokine.

The BMP group of proteins is characterized by a polybasic proteolytic processing site, which is cleaved to produce a protein containing seven conserved cysteine residues. GDF11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The similarities between GDF11 and myostatin imply a likelihood that the same regulatory mechanisms are used to control tissue size during both muscular and neural development.

...
Wikipedia